Abstract | OBJECTIVES: DESIGN: Prospective, observational, longitudinal study. INTERVENTION: The Reducing Use of Sedatives (RedUSe) project involved 150 Australian Long-Term Care Facilities (LTCFs) incorporating auditing and benchmarking of prescribing, education, and multidisciplinary sedative reviews. SETTING: A convenience sample of LTCFs (n = 28) involved in RedUSe between January 2015 and March 2016. PARTICIPANTS: MEASUREMENTS: Neuropsychiatric symptoms (Neuropsychiatric Inventory, Cohen-Mansfield Agitation Inventory (CMAI)), QoL (Assessment of Quality of Life-4D), and social withdrawal (Multidimensional Observation Scale for Elderly Subjects-withdrawal subscale) were measured at baseline and 4 months where nursing staff completed psychometric tests as proxy raters. RESULTS: There was no evidence that psychometric measures were worsened following dose reductions. In fact, dose reduction was associated with small, albeit non-statistically significant, improvements in behavior, particularly less physically non-aggressive behavior with both drug groups (-0.36 points per 10% reduction in antipsychotic dose, -0.17 per 10% reduction in benzodiazepine dose) and verbally agitated behavior with benzodiazepine reduction (-0.16 per 10% dose reduction), as measured with the CMAI. Furthermore, antipsychotic reduction was associated with non-statistically significant improvements in QoL and social withdrawal. CONCLUSIONS:
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Authors | Daniel J Hoyle, Gregory M Peterson, Ivan K Bindoff, Lisa M Clinnick, Aidan D Bindoff, Juanita L Breen |
Journal | International psychogeriatrics
(Int Psychogeriatr)
Vol. 33
Issue 6
Pg. 587-599
(06 2021)
ISSN: 1741-203X [Electronic] England |
PMID | 32618535
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antipsychotic Agents
- Benzodiazepines
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Topics |
- Aged
- Aged, 80 and over
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Australia
- Benzodiazepines
(adverse effects, therapeutic use)
- Drug Therapy
(statistics & numerical data)
- Drug Utilization
- Female
- Homes for the Aged
(statistics & numerical data)
- Humans
- Long-Term Care
(statistics & numerical data)
- Longitudinal Studies
- Male
- Mental Disorders
(drug therapy)
- Middle Aged
- Nursing Homes
(statistics & numerical data)
- Practice Patterns, Physicians'
(statistics & numerical data)
- Prospective Studies
- Quality of Life
(psychology)
- Social Isolation
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