Serum CEA and CYFRA Levels in ALK-rearranged NSCLC Patients: Correlation With Distant Metastasis.

Abstract

AIM:

To clarify the correlation between serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA) and metastasis and survival in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) patients.

PATIENTS AND METHODS:

CEA and CYFRA levels in 131 ALK-rearranged NSCLC patients were determined using fluorescence in situ hybridization (FISH), real time-reverse transcription polymerase chain reaction, and immunohistochemistry, using biopsy specimens, cytology specimens, and plasma specimens. Cut-off value of each marker was determined as 10 ng/ml.

RESULTS:

In logistic regression analysis, higher levels of both markers had a positive relationship with bone metastases, and higher levels of CYFRA was relevant to liver metastases, and multiple-organ metastases. However, these markers were not proven to be poor prognostic factors in Cox's proportional model analysis.

CONCLUSION:

Elevated serum CEA and CYFRA levels seem to provide useful clinical information about presence of bone and liver metastasis and multiple-organ metastases, although they were not a powerful indicator of prognosis. These two markers may suggest the extension of metastasis and would be helpful in considering treatment options.

• Authors: Takeshi Numata, Takeo Endo, Hidetoshi Yanai, Kyoko Ota, Yusuke Yamamoto, Kei Shimizu, Hideyasu Yamada, Kenji Hayashihara, Shinichiro Okauchi, Hiroaki Satoh, Yutaka Yamada, Tomohiro Tamura, Kazuto Saito, Norihiro Kikuchi, Koichi Kurishima, Hiroichi Ishikawa, Hiroko Watanabe, Toshihiro Shiozawa, Nobuyuki Hizawa, Yasunori Funayama, Shigen Hayashi, Hiroyuki Nakamura, Takaaki Yamashita
• Journal: In vivo (Athens, Greece) (In Vivo) 2020 Jul-Aug Vol. 34 Issue 4 Pg. 2095-2100 ISSN: 1791-7549 [Electronic] Greece
• PMID: 32606188 (Publication Type: Journal Article)
• Copyright: Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• Carcinoembryonic Antigen
• KRT19 protein, human
• Keratin-19
• Peptide Fragments
• Keratins
• Anaplastic Lymphoma Kinase

Topics

• Anaplastic Lymphoma Kinase (genetics)
• Antigens, Neoplasm (genetics)
• Biomarkers, Tumor (genetics)
• Carcinoembryonic Antigen (genetics)
• Carcinoma, Non-Small-Cell Lung (genetics)
• Humans
• In Situ Hybridization, Fluorescence
• Keratin-19
• Keratins
• Lung Neoplasms (genetics)
• Peptide Fragments
• Prognosis