Abstract | BACKGROUND: OBJECTIVES: We hypothesized that genetic variation in FcγRs may also influence PLT refractoriness in allo-immunized patients and could help in identifying the patients at risk. PATIENTS/METHODS: Patients with severe PLT refractoriness for whom diagnostic testing for allo-immunization was requested in the period of 2005 to 2013 were retrospectively included. A case-control study was performed comparing patients in whom platelet-reactive antibodies were detected (n = 181) with ethnically matched healthy controls (n = 180) to determine differences in all known functional copy number variations and single nucleotide polymorphisms in FcγRs. RESULTS AND CONCLUSIONS: None of the tested FcγR genetic variations seemed associated with the development of severe PLT refractoriness. In contrast to observations in immune thrombocytopenia, genetic variation in FcγRs does not seem to influence the chance to develop PLT refractoriness. Our results do not support determination of FcγR genetic background as a means to identify patients most at risk for PLT refractoriness.
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Authors | Sietse Q Nagelkerke, Leendert Porcelijn, Judy Geissler, Michael W T Tanck, Elly Huiskes, Robin van Bruggen, Timo K van den Berg, Masja de Haas, Taco W Kuijpers |
Journal | Journal of thrombosis and haemostasis : JTH
(J Thromb Haemost)
Vol. 18
Issue 8
Pg. 2047-2053
(08 2020)
ISSN: 1538-7836 [Electronic] England |
PMID | 32588549
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 International Society on Thrombosis and Haemostasis. |
Chemical References |
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Topics |
- Blood Platelets
- Case-Control Studies
- DNA Copy Number Variations
- Humans
- Platelet Transfusion
- Receptors, IgG
(genetics)
- Retrospective Studies
- Thrombocytopenia
(diagnosis, genetics)
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