Impact of prednisolone dosage in the CHOP regimen for follicular lymphoma: a retrospective study.

Abstract

Rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) is one of the standard regimens for indolent B-cell non-Hodgkin's lymphoma (NHL). It is unclear whether the prednisolone (PSL) dosage affects the therapeutic effect or the adverse event profile. We retrospectively examined 48 patients with indolent B-cell NHL who were treated with R-CHOP (PSL 50 mg/m2/day for 5 days) at our institute between 2006 and 2016. We compared them with 149 patients with indolent B-cell lymphoma who were treated with R-CHOP (PSL 100 mg for 5 days) in the JCOG 0203 trial. The proportions of patients with bulky disease, extranodal involvement, and increased nodal sites were higher at our institute. Nevertheless, there was no difference in the CR rate, PFS, OS or the frequency of adverse events, except for peripheral neuropathy, between the two treatment groups. In our institute, there was no difference in the CR rate, PFS, OS or adverse event profile between patients who received PSL at 60-80 mg/day and at 81-100 mg/day. Patients who received PSL at 60-80 mg/day included many female and light-weight patients. In conclusion, the PSL dose adjusted based on body surface area appeared to be appropriate in terms of efficacy and safety.

• Authors: Takashi Ikeda, Shin-Ichiro Fujiwara, HIrotomo Nakajima, Shin-Ichiro Kawaguchi, Yumiko Toda, Shoko Ito, Shinichi Ochi, Takashi Nagayama, Kiyomi Mashima, Kento Umino, Daisuke Minakata, Hirofumi Nakano, Kaoru Morita, Ryoko Yamasaki, Yasufumi Kawasaki, Masahiro Ashizawa, Chihiro Yamamoto, Kaoru Hatano, Kazuya Sato, Iekuni Oh, Ken Ohmine, Kazuo Muroi, Yoshinobu Kanda
• Journal: International journal of hematology (Int J Hematol) Vol. 112 Issue 3 Pg. 369-376 (Sep 2020) ISSN: 1865-3774 [Electronic] Japan
• PMID: 32529585 (Publication Type: Journal Article)

Chemical References

• R-CHOP protocol
• Rituximab
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisolone
• Prednisone

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Body Surface Area
• Cyclophosphamide (adverse effects, therapeutic use)
• Disease-Free Survival
• Doxorubicin (adverse effects, therapeutic use)
• Drug Dosage Calculations
• Female
• Humans
• Lymphoma, Follicular (drug therapy, mortality)
• Lymphoma, Non-Hodgkin (drug therapy)
• Male
• Middle Aged
• Prednisolone (administration & dosage, adverse effects)
• Prednisone (adverse effects, therapeutic use)
• Remission Induction
• Retrospective Studies
• Rituximab (administration & dosage, adverse effects, therapeutic use)
• Treatment Outcome
• Vincristine (adverse effects, therapeutic use)