Abstract | BACKGROUND: OBJECTIVE: To obtain the prevalence of UIA among females and to assess the relationship between smoking and hypertension with a diagnosis of incidental UIAs. METHODS: A nested case-control study from a cohort of female patients aged between 30 and 60 yr with a brain magnetic resonance angiography (MRA) between 2016 and 2018. Incidental UIAs were compared to patients with normal MRAs. Smoking was characterized as never or former/current smokers. A logistic regression was used to evaluate the association between smoking, hypertension, or both, with a diagnosis of incidental UIAs. RESULTS: A total of 1977 patients had a brain MRA between 2016 and 2018. From 1572 nonsmoker patients, we encountered 30 with an UIA (prevalence: 1.9%). There were 405 patients with a positive smoking history, and 77 patients harbored an UIA (prevalence: 19%). Of 64 aneurysm patients and 130 random controls eligible for the case control, aneurysm patients were more likely to have a positive smoking history and hypertension compared with healthy controls (60% vs 18%, P ≤ .001; 44% vs 14%, P ≤ .001). A multivariable analysis demonstrated a significant association between a smoking history, hypertension, or both factors with an incidental UIA (odds ratio [OR] 5.8 CI 1.22-11.70; OR 3.8 CI 2.31-14.78; OR 12.6 CI 4.38-36.26; respectively). CONCLUSION: Females who smoke cigarettes have a higher prevalence of UIAs than the general population. Smoking confers a higher risk for having a silent UIA, aggravated by hypertension. This population is an ideal target for potential screening.
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Authors | Christopher S Ogilvy, Santiago Gomez-Paz, Kimberly P Kicielinski, Mohamed M Salem, Georgios A Maragkos, Michelle Lee, David Vergara-Garcia, Rafael Rojas, Justin M Moore, Ajith J Thomas |
Journal | Neurosurgery
(Neurosurgery)
Vol. 87
Issue 6
Pg. 1191-1198
(11 16 2020)
ISSN: 1524-4040 [Electronic] United States |
PMID | 32521003
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 by the Congress of Neurological Surgeons. |
Chemical References |
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Topics |
- Adult
- Case-Control Studies
- Female
- Humans
- Intracranial Aneurysm
(diagnostic imaging, epidemiology, etiology)
- Middle Aged
- Non-Smokers
- Risk Factors
- Tobacco Smoke Pollution
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