Potential link of single nucleotide polymorphisms to virulence of vaccine-associated field strains of lumpy skin disease virus in South Africa.

Abstract

South Africa is endemic for lumpy skin disease and is therefore reliant on various live attenuated vaccines for the control and prevention of the disease. In recent years, widespread outbreaks of vaccine-like strains of lumpy skin disease virus (LSDV) were reported internationally, leading to an increase in the generation of full genome sequences from field isolates. In this study, the complete genomes of six LSDVs submitted during active outbreaks in the 1990s in South Africa were generated. Based on phylogenetic analysis, the six viruses clustered with vaccine strains in LSDV Subgroup 1.1 and are subsequently referred to as vaccine-associated. The genetic differences between the phenotypically distinct vaccine and vaccine-associated strains were 67 single nucleotide polymorphisms (SNPs). This study characterized the location and possible importance of each of these SNPs in their role during virulence and host specificity.

• Authors: Antoinette van Schalkwyk, Pravesh Kara, Karen Ebersohn, Arshad Mather, Cornelius Henry Annandale, Estelle Hildegard Venter, David Brian Wallace
• Journal: Transboundary and emerging diseases (Transbound Emerg Dis) Vol. 67 Issue 6 Pg. 2946-2960 (Nov 2020) ISSN: 1865-1682 [Electronic] Germany
• PMID: 32506755 (Publication Type: Journal Article)
• Copyright: © 2020 Agricultural Research Council. Transboundary and Emerging Diseases published by Wiley-VCH GmbH.

Chemical References

• Viral Vaccines

Topics

• Animals
• Cattle
• Lumpy Skin Disease (virology)
• Lumpy skin disease virus (genetics, pathogenicity)
• Polymorphism, Single Nucleotide
• South Africa
• Viral Vaccines (immunology)
• Virulence