Circulating microRNAs vs. aortic diameter in bicuspid aortic valve aortopathy.

Abstract

There is growing clinical need and interest to implement novel risk prediction tools in bicuspid aortic valve-associated proximal aortic disease, so-called bicuspid aortic valve aortopathy. Inherent limitations of the diameter-based risk stratification for adverse aortic events in bicuspid aortic valve aortopathy patients have recently been recognized. Therefore, alternative diagnostic tools and subsequent adjustments in the treatment guidelines are urgently needed. Herein, we summarize the current evidence on recent diagnostic developments to improve risk stratification in bicuspid aortic valve aortopathy, including circulating microRNAs as biomarkers to predict the progression of aortic disease.

• Authors: Shiho Naito, Johannes Petersen, Tatiana Sequeira-Gross, Tanja Zeller, Hermann Reichenspurner, Evaldas Girdauskas
• Journal: Asian cardiovascular & thoracic annals (Asian Cardiovasc Thorac Ann) Vol. 30 Issue 8 Pg. 947-953 (Oct 2022) ISSN: 1816-5370 [Electronic] England
• PMID: 32498553 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers
• Circulating MicroRNA

Topics

• Aortic Diseases
• Aortic Valve (diagnostic imaging, surgery)
• Bicuspid Aortic Valve Disease
• Biomarkers
• Circulating MicroRNA
• Heart Valve Diseases (complications, diagnostic imaging, genetics)
• Humans
• Treatment Outcome