Tumor-infiltrating Lymphocyte Score Based on FDG PET/CT for Predicting the Effect of Neoadjuvant Chemotherapy in Breast Cancer.

Abstract

AIM:

To investigate whether tumor-infiltrating lymphocyte (TIL) scoring based on 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) can predict the pathological response to neoadjuvant chemotherapy.

PATIENTS AND METHODS:

A total of 261 patients with breast cancer underwent complete resection after neoadjuvant chemotherapy. PET-TIL score was calculated using tumor size, Ki-67 labeling index, and maximum standardized uptake value (SUVmax) on FDG PET/CT. The efficacy of the PET-TIL score in predicting the pathological complete response (pCR) was retrospectively evaluated.

RESULTS:

pCR rates were 11.4%, 58.6%, and 38.8% in luminal, human epidermal growth factor receptor 2 (HER2)-positive, and triple-negative breast cancer, respectively. The corresponding median PET-TIL scores were 28, 37, and 45. pCR rates were 20.0% and 44.2% in the low and high PET-TIL score groups, respectively (p<0.001). HER2-positive and triple-negative subtypes and high PET-TIL score were independent predictors for pCR.

CONCLUSION:

PET-TIL score can predict pCR after neoadjuvant chemotherapy in breast cancer.

• Authors: Shinsuke Sasada, Yuri Kimura, Akiko Emi, Norio Masumoto, Takayuki Kadoya, Koji Arihiro, Morihito Okada
• Journal: Anticancer research (Anticancer Res) Vol. 40 Issue 6 Pg. 3395-3400 (Jun 2020) ISSN: 1791-7530 [Electronic] Greece
• PMID: 32487636 (Publication Type: Journal Article)
• Copyright: Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• Fluorodeoxyglucose F18

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Biomarkers, Tumor
• Breast Neoplasms (diagnostic imaging, drug therapy, mortality, pathology)
• Female
• Fluorodeoxyglucose F18
• Humans
• Lymphocytes, Tumor-Infiltrating (metabolism, pathology)
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Grading
• Neoplasm Staging
• Positron Emission Tomography Computed Tomography (methods)
• Prognosis
• ROC Curve
• Treatment Outcome
• Tumor Microenvironment
• Young Adult