Sex differences between Helicobacter pylori infection and cholesterol levels in an adult health checkup program.

Abstract

BACKGROUND:

Helicobacter pylori (H pylori) infection is suggested to be a risk factor of metabolic syndrome (MS) and lipid abnormalities. The aim of this study was to investigate the influence of H pylori infection on MS and lipid abnormalities according to sex differences.

MATERIALS AND METHODS:

We analyzed a total of 4551 adults who received health checkups from January 2016 to May 2017. We enrolled participants who did not have a history of hypertension, diabetes, hyperlipidemia, or cancer among those who underwent endoscopy with a rapid urease test.

RESULTS:

We included a total of 1065 participants, and 663 patients (62.3%) were H pylori-positive. The H pylori infection rate was 59.3% (426/719) in males and 68.5% (237/346) in females. The mean level of total cholesterol (P = .003), low-density lipoprotein (LDL) cholesterol (P = .046), and triglycerides (P = .029) were statistically higher in H pylori-infected males. The mean level of high-density lipoprotein (HDL) cholesterol was statistically lower in H pylori-infected females (P = .032). Multivariate analysis showed that total cholesterol in males (odds ratio [OR], 1.007; 95% confidence interval [CI], 1.002-1.011) and HDL cholesterol in females (OR, 0.983; 95% CI, 0.968-0.998) were associated with active H pylori infection. The prevalence of MS was higher in both male and female H pylori-infected groups; however, there was no statistical significance.

CONCLUSIONS:

H pylori infection is significantly related to increased total cholesterol in males and to decreased HDL cholesterol in females, which suggests that H pylori could affect lipid profiles and may be different by sex.

• Authors: Kwang Il Seo, Jae Joon Heo, Sung Eun Kim, Seun Ja Park, Moo In Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Dae Hyeon Cho
• Journal: Helicobacter (Helicobacter) Vol. 25 Issue 4 Pg. e12704 (Aug 2020) ISSN: 1523-5378 [Electronic] England
• PMID: 32458524 (Publication Type: Journal Article)
• Copyright: © 2020 John Wiley & Sons Ltd.

Chemical References

• Cholesterol, HDL
• Cholesterol

Topics

• Adult
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Female
• Helicobacter Infections (blood, diagnosis, epidemiology)
• Helicobacter pylori (isolation & purification)
• Humans
• Male
• Metabolic Syndrome (blood, diagnosis, epidemiology)
• Middle Aged
• Odds Ratio
• Prevalence
• Republic of Korea (epidemiology)
• Sex Factors