Abstract | PURPOSE: METHODS: A prospective observational cohort study was performed during a 5-year time-period on adult patients with isolated TBI admitted to an academic level I trauma center in the United States. Controls consisted of patients with femur shaft fractures with or without TBI to mitigate the effect of systemic complement activation by peripheral trauma. Healthy volunteers served as internal controls. The sC5b-9 serum concentrations were measured on the day of admission by enzyme-linked immunosorbent assay (ELISA) and compared between the study cohorts. Univariate analysis was performed to determine independent predictive variables of major complications during hospital admission. RESULTS: Serum sC5b-9 levels were significantly elevated in patients with isolated TBI (n = 42), compared to patients with isolated femoral shaft fractures (n = 36) or combined TBI and femoral shaft fractures (n = 30; p < 0.05). There was no significant difference in serum sC5b-9 levels between the femur group and the combined injury group, compared to the healthy volunteers (n = 21). Univariate analysis revealed serum sC5b-9 levels as an independent predictor of major postinjury complications after isolated TBI (p < 0.01). CONCLUSION:
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Authors | Joshua Parry, Jiho Hwang, Cedric F Stahel, Corey Henderson, Jason Nadeau, Stephen Stacey, Kathryn Beauchamp, Ernest E Moore, Philip F Stahel |
Journal | European journal of trauma and emergency surgery : official publication of the European Trauma Society
(Eur J Trauma Emerg Surg)
Vol. 47
Issue 5
Pg. 1491-1497
(Oct 2021)
ISSN: 1863-9941 [Electronic] Germany |
PMID | 32451568
(Publication Type: Journal Article, Observational Study)
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Copyright | © 2020. Springer-Verlag GmbH Germany, part of Springer Nature. |
Chemical References |
- Biomarkers
- Complement Membrane Attack Complex
- Complement System Proteins
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Topics |
- Biomarkers
- Brain Injuries, Traumatic
- Complement Activation
- Complement Membrane Attack Complex
- Complement System Proteins
- Humans
- Prospective Studies
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