Incidence of herpes zoster among varicella-vaccinated children, by number of vaccine doses and simultaneous administration of measles, mumps, and rubella vaccine.
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| Abstract | INTRODUCTION: Children may receive measles-mumps-rubella (MMR) and varicella (VAR) vaccines separately or as measles-mumps-rubella-varicella (MMRV). We examined whether pediatric herpes zoster (HZ) incidence varied by pattern of varicella vaccine administration. METHODS: In six integrated health systems, we examined HZ incidence among children turning 12 months old during 2003-2008. All received varicella and MMR vaccines on recommended schedules. Cases were identified through 2014 using ICD-9 codes. Incidence was examined by number of varicella vaccine doses and same-day MMR. RESULTS: Among 199,797 children, overall HZ incidence was 18.6/100,000 person-years in the first-dose MMR + VAR group, 17.9/100,000 person-years in the MMRV group, and 7.5/100,000 person-years in the VAR-alone group. HZ incidence was lower following the second dose than before the second dose in all first-dose groups. CONCLUSIONS: HZ incidence was not meaningfully different between the MMRV and MMR + VAR first-dose groups. Overall and within first-dose groups, HZ incidence was lower among children receiving two varicella vaccine doses.
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| Authors | Sheila Weinmann, Stephanie A Irving, Padma Koppolu, Allison L Naleway, Edward A Belongia, Simon J Hambidge, Michael L Jackson, Nicola P Klein, Bruno Lewin, Elizabeth Liles, Mona Marin, Ning Smith, Eric Weintraub, Colleen Chun |
| Journal | Vaccine (Vaccine) Vol. 38 Issue 37 Pg. 5880-5884 (08 18 2020) ISSN: 1873-2518 [Electronic] Netherlands |
| PMID | 32444193 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.) |
| Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
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