Myosin heavy chain 11 (MYH11), encoded by the MYH11 gene, is a
protein that participates in muscle contraction through the hydrolysis of
adenosine triphosphate. Although previous studies have demonstrated that MYH11 gene expression levels are downregulated in several types of
cancer, its expression levels have rarely been investigated in
lung cancer. The present study aimed to explore the clinical significance and prognostic value of MYH11 expression levels in
lung cancer and to further study the underlying molecular mechanisms of the function of this gene. The Oncomine database showed that the MYH11 expression levels were decreased in
lung cancer compared with those noted in the normal lung tissue (P<0.05). Kaplan-Meier plotter results revealed that the decreased MYH11 expression levels were correlated with poor prognosis in
lung cancer patients. Among the
lung cancer cases with gene alteration of MYH11, mutation was the most common of all alteration types. Coexpedia and Metascape analyses revealed that the target genes were primarily enriched in 'muscle contraction', 'contractile fiber part', 'actin cytoskeleton' and the 'adherens junction'. These results indicated that MYH11 is a potential novel drug target and prognostic
indicator of
lung cancer.