Abstract |
A new monoclonal antibody designated FO23C5 against a protein component of carcinoembryonic antigen (CEA) has been developed. A xenograft system of human colon cancer was used to compare the intact monoclonal IgG with its fragments (Fab')2 and Fab) and with an established anti-CEA antibody ( MAb35) and the antibody AUA1 raised against the colon carcinoma cell line. We demonstrate that FO23C5 compares well with the existing anti-CEA antibody and with AUA1, and that F(ab')2 fragments perform best in achieving optimal tumour to normal tissue ratios compared with intact IgG and Fab fragment.
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Authors | G Rowlinson, G Paganelli, D Snook, A A Epenetos |
Journal | The International journal of biological markers
(Int J Biol Markers)
1988 Oct-Dec
Vol. 3
Issue 4
Pg. 259-64
ISSN: 0393-6155 [Print] United States |
PMID | 3235854
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Carcinoembryonic Antigen
- Immunoglobulin Fab Fragments
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Topics |
- Adenocarcinoma
(diagnostic imaging)
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Carcinoembryonic Antigen
(immunology)
- Cell Line
- Colonic Neoplasms
(diagnostic imaging)
- Female
- Humans
- Immunoglobulin Fab Fragments
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Radionuclide Imaging
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