Increased Prostate-Specific Membrane Antigen Uptake in Neurofibromatosis.

Abstract

A 51-year-old man with 30-year neurofibromatosis and 2-month elevated prostate-specific antigen and back pain underwent a Ga-prostate-specific membrane antigen (PSMA) PET/CT scan for possible prostate cancer. Prostate-specific membrane antigen PET/CT imaging showed no abnormal uptake of the prostate. However, in addition to PSMA uptake in his left lung, thorax, and right ilium, which was confirmed being a lung squamous cell carcinoma by a lung biopsy, widespread uptake was also observed in his skin fibroma lesions. This case demonstrates that benign neurofibromatosis could have uptake of PSMA.

• Authors: Yingwei Wang, Cheng Zeng, Huipan Liu, Yue Chen, Wei Zhang
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 45 Issue 6 Pg. 465-467 (Jun 2020) ISSN: 1536-0229 [Electronic] United States
• PMID: 32332318 (Publication Type: Case Reports, Journal Article)

Chemical References

• Gallium Isotopes
• Gallium Radioisotopes
• Membrane Glycoproteins
• Organometallic Compounds
• gallium 68 PSMA-11

Topics

• Biological Transport
• Gallium Isotopes
• Gallium Radioisotopes
• Humans
• Male
• Membrane Glycoproteins (metabolism)
• Middle Aged
• Neurofibromatoses (diagnostic imaging, metabolism)
• Organometallic Compounds (metabolism)
• Positron Emission Tomography Computed Tomography