Abstract | AIM: METHODS: Serum troponin was sampled in infants requiring resuscitation at birth and/or neonatal encephalopathy in a tertiary referral neonatal centre. Birth history, clinical parameters, neuroimaging and developmental outcome (Bayley Scores of Infant Development [BSID] III) were evaluated. RESULTS: Infants with perinatal asphyxia (n = 54) had serum troponin T measured and 27 required therapeutic hypothermia. Troponin T levels on days 1 and 2 were predictive of need for TH, development of seizures and grade II/III NE (AUC = 0.7; P-values < .001), troponin T levels on days 1, 2 and 3 were highly significant predictors of mortality (AUC = 0.99, P-values .005). The cut-off values of troponin T for best prediction of mortality were 0.84, 0.63 and 0.58 ng/mL on days 1, 2 and 3, respectively. Troponin T on day 3 of life was predictive of injury in the combined area of basal ganglia/watershed on MRI (AUC 0.70; P-value = .045). CONCLUSION: Infants with brain injury on neuroimaging following perinatal asphyxia had significantly elevated serum troponin, and troponin also correlated with developmental scores at 2 years. Further studies combining troponin and MRI may assist in the classification of neonatal brain injury to define aetiology, prognosis and response to treatment.
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Authors | Deirdre U Sweetman, Lynne Kelly, Tim Hurley, Chike Onwuneme, R William Gordon Watson, John F A Murphy, Marie Slevin, Veronica Donoghue, Eleanor J Molloy |
Journal | Acta paediatrica (Oslo, Norway : 1992)
(Acta Paediatr)
Vol. 109
Issue 11
Pg. 2266-2270
(11 2020)
ISSN: 1651-2227 [Electronic] Norway |
PMID | 32281692
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Adult
- Asphyxia Neonatorum
(complications, diagnostic imaging, therapy)
- Child
- Female
- Humans
- Hypothermia, Induced
- Hypoxia-Ischemia, Brain
(diagnostic imaging, therapy)
- Infant
- Infant, Newborn
- Magnetic Resonance Imaging
- Pregnancy
- Troponin T
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