The miR-582/CD1B Axis Is Involved in Regulation of Dendritic Cells and Is Associated with Clinical Outcomes in Advanced Lung Adenocarcinoma.

Abstract

The involvement of immune dysfunction in the pathogenesis of lung cancer has been extensively studied. However, the potential molecular mechanisms through which the tumor immune response affects drug resistance are still unclear. Accordingly, in this study, we evaluated deviations in the immune cell landscape among patients with different stages of lung adenocarcinoma to identify key microRNAs and their targets associated with patient outcomes. CIBERSORT was used for estimating the proportions of immune cells in various lung tissues. Significantly different adaptive and innate immune cell types, including memory B cells, CD8+ T cells, resting dendritic cells, and resting mast cells, were selected. Comparative studies and survival analyses were carried out. We found that potential genes and microRNAs involved in immune responses were associated with patient outcomes. Specifically, miR-582/CD1B, which are involved in resting and activated dendritic cells, may be potential novel biomarkers for immunotherapy. An independent dataset of miRNA microarray profiles was used to validate the expression of mature miR-582-5p in patients with advanced lung adenocarcinoma. Alternative treatments, including immunotherapies and chemotherapy, are urgently needed to improve outcomes in patients with lung cancer. Thus, our findings could provide insights into the selection of novel microRNAs targeting immune genes and could improve the efficacy of immunotherapy by disrupting tumor function and promoting immune infiltration in patients with advanced lung adenocarcinoma.

• Authors: Jun Guo, Hui Jin, Yanfeng Xi, Jian Guo, Yi Jin, Da Jiang
• Journal: BioMed research international (Biomed Res Int) Vol. 2020 Pg. 4360930 ( 2020) ISSN: 2314-6141 [Electronic] United States
• PMID: 32258122 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Jun Guo et al.

Chemical References

• Antigens, CD1
• Biomarkers, Tumor
• CD1b antigen
• MIRN582 microRNA, human
• MicroRNAs

Topics

• Adenocarcinoma of Lung (drug therapy, genetics, immunology, pathology)
• Antigens, CD1 (genetics)
• Biomarkers, Tumor (genetics)
• Dendritic Cells (drug effects, immunology)
• Drug Resistance, Neoplasm (genetics)
• Female
• Gene Expression Regulation, Neoplastic (genetics)
• Humans
• Immunotherapy (adverse effects)
• Male
• MicroRNAs (genetics)
• Neoplasm Staging
• Progression-Free Survival
• Signal Transduction (genetics)
• Treatment Outcome