A potential urinary biomarker to determine frailty status among older adults.

Abstract

BACKGROUND:

Association of oxidative stress biomarkers with aging and several age-related diseases is well documented. However, the possible role of these factors on frailty status in older adults has not been extensively studied.

OBJECTIVE:

To evaluate whether urinary 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), a biomarker of RNA oxidative damage, was independently associated with frailty.

METHODS:

In this cross-sectional analysis, frailty phenotype was assessed among 230 participants living in a senior community. Participants received a comprehensive geriatric assessment. Serum high-sensitivity C-reactive protein (hsCRP), white blood cell count (WBC), urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine, and 8-oxo-Gsn were measured.

RESULTS:

Participants' mean age was 83.9 ± 4.4 years. In total, 33 % were frail, 45 % were pre-frail, and 22 % were non-frail. Urinary 8-oxo-Gsn, serum hsCRP, and WBC were significantly higher in the frail group than in the non-frail and pre-frail groups (p-values < 0.05). Adjusting for age, sex, and Charlson comorbidity index, statistically significant positive associations with frailty were observed for urinary 8-oxo-Gsn (odds ratio [OR]: 1.70, 95 % confidence interval [CI]: 0.264-0.732) and hsCRP (OR: 1.337, 95 % CI: 0.089-0.412). Urinary 8-oxo-Gsn of 3.175 μmol/mol had the optimal predictive value for frailty, with an area under the receiver operating characteristic curve (AUC) of 0.72 (95 % CI: 0.649-0.788). The prediction probability combining urinary 8-oxo-Gsn and a simple question evaluating exhaustion had the optimal predictive value for frailty, with an AUC of 0.90 (p < 0.001, 95 % CI: 0.85-0.95).

CONCLUSION:

Urinary 8-oxo-Gsn level was independently associated with frailty. This urinary biomarker may be a promising indicator of frailty.

• Authors: Shan Jiang, Lin Kang, Minglei Zhu, Xu Zhang, Chenchen Wang, Jianping Cai, Xiaohong Liu
• Journal: Archives of gerontology and geriatrics (Arch Gerontol Geriatr) 2020 May - Jun Vol. 88 Pg. 104038 ISSN: 1872-6976 [Electronic] Netherlands
• PMID: 32229368 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020. Published by Elsevier B.V.

Chemical References

• Biomarkers
• Guanosine
• 8-hydroxyguanosine

Topics

• Aged
• Aged, 80 and over
• Biomarkers (urine)
• Cross-Sectional Studies
• Frail Elderly
• Frailty (diagnosis)
• Geriatric Assessment
• Guanosine (analogs & derivatives, urine)
• Humans
• Odds Ratio