Efficacy of Low-Dose Aripiprazole for Treatment of Psychotic Symptoms in a Patient with 22q11.2 Deletion Syndrome.

Abstract

Objectives:

The 22q11.2 deletion syndrome is one of the most prevalent genetic disorders and children suffering from this syndrome have been found to have a substantially greater risk for the development of schizophrenia and bipolar disorder. Psychiatric medications such as antipsychotics are commonly used in individuals with 22q11.2DS.

Experimental Design:

This is a case of 13 years male young man suffering from 22q11.2 deletion syndrome. Since adolescence, he presented with behavioural disorders, aggression, verbal abuse, sleep disorders.

Principal Observations:

The psychiatric examination confirmed the delusional idea, which was repeated in an obsessive way. There were also auditory hallucinations along with reference ideas. Aripiprazole was administered in 8 mg daily which gave more spectacular results and was better tolerated.

Conclusions:

In the present situation delusional ideas are no longer mentioned, but a cognitive deduction is found. Aripiprazole can be an effective pharmacological solution for the psychotic symptoms in patients suffering from 22q11DS.

• Authors: Konstantinos Kontoangelos, Eleni Lazaratou, Marina Economou, Konstantina G Yiannopoulou, Charalambos C Papageorgiou
• Journal: Psychopharmacology bulletin (Psychopharmacol Bull) Vol. 50 Issue 1 Pg. 35-39 (03 12 2020) ISSN: 2472-2448 [Electronic] United States
• PMID: 32214520 (Publication Type: Case Reports)
• Copyright: Copyright © 1964–2020 by MedWorks Media Inc, Los Angeles, CA All rights reserved. Printed in the United States.

Chemical References

• Aripiprazole

Topics

• Adolescent
• Aripiprazole
• Child
• DiGeorge Syndrome (complications, drug therapy)
• Hallucinations
• Humans
• Male
• Psychotic Disorders (drug therapy)
• Schizophrenia (drug therapy)