Gold Nanoparticles in Glioma Theranostics.

Abstract

Despite many endeavors to treat malignant gliomas in the last decades, the median survival of patients has not significantly improved. The infiltrative nature of high-grade gliomas and the impermeability of the blood-brain barrier to the most therapeutic agents remain major hurdles, impeding an efficacious treatment. Theranostic platforms bridging diagnosis and therapeutic modalities aim to surmount the current limitations in diagnosis and therapy of glioma. Gold nanoparticles (AuNPs) due to their biocompatibility and tunable optical properties have widely been utilized for an assortment of theranostic purposes. In this Review, applications of AuNPs as imaging probes, drug/gene delivery systems, radiosensitizers, photothermal transducers, and multimodal theranostic agents in malignant gliomas are discussed. This Review also aims to provide a perspective on cancer theranostic applications of AuNPs in future clinical trials.

• Authors: Mohammad Norouzi
• Journal: Pharmacological research (Pharmacol Res) Vol. 156 Pg. 104753 (06 2020) ISSN: 1096-1186 [Electronic] Netherlands
• PMID: 32209363 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Drug Carriers
• Gold Compounds

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Brain Neoplasms (diagnostic imaging, pathology, therapy)
• Drug Carriers
• Gene Transfer Techniques
• Genetic Therapy
• Glioma (diagnostic imaging, pathology, therapy)
• Gold Compounds (adverse effects, therapeutic use)
• Humans
• Immunotherapy
• Metal Nanoparticles (adverse effects, therapeutic use)
• Molecular Imaging
• Photochemotherapy
• Photothermal Therapy
• Predictive Value of Tests
• Theranostic Nanomedicine