Dietary intake of choline and phosphatidylcholine and risk of type 2 diabetes in men: The Kuopio Ischaemic Heart Disease Risk Factor Study.

Abstract

PURPOSE:

To investigate associations of total dietary choline intake and its major dietary form, phosphatidylcholine, with type 2 diabetes risk.

METHODS:

We included 2332 men aged 42-60 years at baseline in 1984-1989 from the Kuopio Ischaemic Heart Disease Risk Factor Study in eastern Finland. Dietary intakes were assessed with 4-d food recording at baseline. Type 2 diabetes diagnosis was based on self-administered questionnaires, fasting and 2-h oral glucose tolerance test blood glucose measurements, or by record linkage to national health registries. Multivariable-adjusted Cox proportional hazards regression models were used for statistical analysis.

RESULTS:

During the mean 19.3-year follow-up, 432 men had type 2 diabetes diagnosis. After multivariable adjustments, those in the highest vs. lowest choline intake quartile had 25% (95% CI 2-43%) lower relative risk (P trend across quartiles = 0.02) and those in the highest vs. lowest phosphatidylcholine quartile had 41% (95% CI 22-55%) lower relative risk (P trend < 0.001) of type 2 diabetes.

CONCLUSIONS:

Higher choline intake, especially phosphatidylcholine, was associated with lower type 2 diabetes risk among men.

• Authors: Jyrki K Virtanen, Tomi-Pekka Tuomainen, Sari Voutilainen
• Journal: European journal of nutrition (Eur J Nutr) Vol. 59 Issue 8 Pg. 3857-3861 (Dec 2020) ISSN: 1436-6215 [Electronic] Germany
• PMID: 32198672 (Publication Type: Journal Article)

Chemical References

• Phosphatidylcholines
• Choline

Topics

• Choline
• Diabetes Mellitus, Type 2 (epidemiology)
• Diet
• Eating
• Finland (epidemiology)
• Heart Disease Risk Factors
• Humans
• Male
• Phosphatidylcholines
• Prospective Studies
• Risk Factors