The Expression, Clinicopathologic Characteristics, and Prognostic Value of Androgen Receptor in Breast Cancer: A Bioinformatics Analysis Using Public Databases.

Abstract

The role of androgen receptor (AR) in breast cancer has been unveiled in succession for the past few years. In this study, we conducted a comprehensive analysis based on four online public databases of data from many previous studies. We found that the expression of AR is significantly related to age, histological grade, and subtype but not to lymph node status. The low expression level of AR is strongly associated with poor recurrence-free survival, especially with poor distance metastasis-free survival in luminal A patients, but inverse in HER2 (human epidermal growth factor receptor-2) enriched patients. AR might be a biomarker of chemosensitivity in the basal subtype. Besides, the expression of melanophilin (MLPH) is distinctly in accordance with that of AR. AR could play diverse roles in different subtypes of breast cancer.

• Authors: Wen-Fen Fu, Juan-Juan Li, Shao-Hong Kang, Chuan-Gui Song
• Journal: DNA and cell biology (DNA Cell Biol) Vol. 39 Issue 5 Pg. 864-874 (May 2020) ISSN: 1557-7430 [Electronic] United States
• PMID: 32181676 (Publication Type: Journal Article)

Chemical References

• RNA, Messenger
• Receptors, Androgen

Topics

• Breast Neoplasms (diagnosis, genetics, pathology)
• Computational Biology
• Databases, Genetic
• Evolution, Molecular
• Female
• Humans
• Middle Aged
• Prognosis
• RNA, Messenger (genetics)
• Receptors, Androgen (genetics)