Age-specific vaccination coverage estimates for influenza, human papillomavirus and measles containing vaccines from seven population-based healthcare databases from four EU countries - The ADVANCE project.

Abstract

BACKGROUND:

The Accelerated Development of VAccine beNefit-risk Collaboration in Europe (ADVANCE) is a public-private collaboration aiming to develop and test a system for rapid benefit-risk monitoring of vaccines using existing healthcare databases in Europe. We estimated vaccine coverage from electronic healthcare databases as part of a fit-for-purpose assessment for vaccine benefit-risk studies.

METHODS:

A retrospective dynamic cohort study was conducted through a distributed network approach. Coverage with measles-vaccine for birth year 2006, human papillomavirus (HPV)-vaccine for birth years 1990-2000 and influenza-vaccine for birth years 1920-1950 was estimated using period-prevalence and inverse probability weighting methods. Seven databases from four countries participated: Italy (Pedianet, Val Padana), Spain (BIFAP, SIDIAP), UK (RCGP-RSC, THIN), Denmark (SSI/AUH). Database access providers extracted the data, transformed it into a common structure and ran an R-script locally. The created output tables were shared and pooled at a central server.

RESULTS:

The total study population comprised 274,616 persons for measles-vaccine, 2,011,666 persons for HPV-vaccine and 14,904,033 persons for influenza-vaccine. Measles-vaccine coverage varied from 84.3% (Denmark) to 96.5% (Italy, Val Padana) for the first dose and from 82.8% (Italy, Val Padana) to 90.9% (UK) for the second dose at the age of 7 years. The HPV-vaccine coverage, aggregated over birth years 1997-2000, ranged from 60% (UK) to 88.3% (Denmark) at the age of 15 years. The influenza-vaccine coverage for the influenza seasons from 2009 to 2015 for persons aged 65 years and more was roughly stable around 43% in Denmark and around 68% in the UK while a decrease from 58 to 50% was observed in Catalonia (Spain).

CONCLUSIONS:

We obtained detailed, age-specific coverage estimates though a common procedure. We discussed between database comparability and comparability to published national estimates.

• Authors: Toon Braeye, Hanne-Dorthe Emborg, Ana Llorente-García, Consuelo Huerta, Elisa Martín-Merino, Talita Duarte-Salles, Giorgia Danieli, Lara Tramontan, Daniel Weibel, Chris McGee, Marco Villa, Rosa Gini, Matti Lehtinen, Lina Titievsky, Miriam Sturkenboom
• Journal: Vaccine (Vaccine) Vol. 38 Issue 16 Pg. 3243-3254 (04 03 2020) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 32171573 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Chemical References

• Papillomavirus Vaccines
• Pertussis Vaccine

Topics

• Adolescent
• Age Factors
• Aged
• Alphapapillomavirus
• Child
• Cohort Studies
• Delivery of Health Care
• Europe (epidemiology)
• Humans
• Influenza, Human (epidemiology, prevention & control)
• Italy (epidemiology)
• Measles
• Papillomaviridae
• Papillomavirus Vaccines
• Pertussis Vaccine
• Retrospective Studies
• Spain
• Vaccination
• Vaccination Coverage