Circulating MiR-29a, Possible Use as a Biomarker for Monitoring IgA Nephropathy.

Abstract

INTRODUCTION:

Previous studies have shown that TGF-β1/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. To date, only few studies have reportedon circulating microRNAs in IgA nephropathy (IgAN). However, the plasma expression of miR-29a and its role in patients with IgAN remains unclear. In this study, we attempted to elucidate whether plasma miR-29a expression can be used as a biomarker for monitoring disease states.

METHODS:

For this study, 15 healthy subjects, 36 patients with untreated renal biopsy-proven IgAN, and 79 patients with IgAN, who were under treatment for a period of 1 year on an average, all of whom had similar age and gender distributions, were included. The plasma expression of miR-29a in each group was explored by real-time PCR, and the relationship between miR-29a expression and clinical, pathological, and prognostic indicators of IgAN was further evaluated.

RESULTS:

Relative plasma expression of miR-29a in patients with IgAN was significantly lower than that in healthy controls (P < .001), and these changes in plasma miR-29a could be suppressed by treatment (P < .05). Plasma miR-29a was positively correlated with eGFR and negatively correlated with proteinuria and serum creatinine, irrespective of whether or not the patients with IgAN accepted treatment (P < .05). Plasma miR-29a level was negatively correlated with primary pathological parameters such as crescent formation, Lee's and Oxford classification (P < .05). Kaplan-Meier analysis revealed that patients with high plasma expression of miR-29a had better renal function and better response to treatment compared to those with low expression (P < .05).

CONCLUSION:

Plasma miR-29a could be considered as a biological marker that reflects renal damage and function, to predict the progression of IgAN.

• Authors: Haofei Hu, Qijun Wan, Tong Li, Dongli Qi, Xu Dong, Yi Xu, Hongtao Chen, Hongping Liu, Haogui Huang, Cuimei Wei, Wenxiong Zhou, Shilun Jiang, Zihe Mo, Fupeng Liao, Qitao Xu, Yongcheng He
• Journal: Iranian journal of kidney diseases (Iran J Kidney Dis) Vol. 14 Issue 2 Pg. 107-118 (03 2020) ISSN: 1735-8604 [Electronic] Iran
• PMID: 32165595 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• MIRN29a microRNA, human
• MicroRNAs
• Creatinine

Topics

• Adult
• Biomarkers (blood)
• Case-Control Studies
• Creatinine (blood)
• Disease Progression
• Female
• Glomerular Filtration Rate
• Glomerulonephritis, IGA (blood, pathology)
• Humans
• Kidney (physiopathology)
• Male
• MicroRNAs (blood)
• Prognosis