Abstract | BACKGROUND: METHODS: RESULTS: When DOX was used as a model drug, the drug-loaded SS-PU- SS-PEG micelles were about 82∼94 nm in diameter and exhibited good stability in phosphate buffer saline (PBS). The micelles could release about 80% DOX in a quantitative fashion within 5 hours under a reductive environment. The intracellular drug release of DOX-loaded SS-PU- SS-PEG micelles increased upon incubation with Saos-2 cells in vitro. The micelles had good biocompatibility. In vitro, DOX-loaded SS-PU- SS-PEG micelles showed significant antitumor activity toward Saos-2 cells, which was close to that of free DOX. In vivo, DOX-loaded SS-PU- SS-PEG micelles exhibited better antitumor activity than free DOX. CONCLUSION: Findings from this study suggest that the SS-PU- SS-PEG micelles could achieve well-controlled triggered drug release in a reduction environment and could therefore improve the antitumor efficacy of osteosarcoma therapies. TRANSLATION POTENTIAL OF THIS ARTICLE: In this study we developed PEG-sheddable reduction-sensitive polyurethane micelles (SS-PU- SS-PEG), which were able to achieve well-controlled triggered release of anti- tumor drug Doxorubicin (DOX) in an intracellular reduction environment. DOX-loaded SS-PU- SS-PEG micelles markedly improved the antitumor efficacy in a Saos-2 cells-bearing xenograft tumor model. Therefore, such micelles might be used as a novel drug delivery system for osteosarcoma treatment.
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Authors | Zhengjie Yang, Qianping Guo, Yan Cai, Xuesong Zhu, Caihong Zhu, Yuling Li, Bin Li |
Journal | Journal of orthopaedic translation
(J Orthop Translat)
Vol. 21
Pg. 57-65
(Mar 2020)
ISSN: 2214-031X [Print] Singapore |
PMID | 32099805
(Publication Type: Journal Article)
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Copyright | © 2019 The Author(s). |