A separation of clinical from epidermal thinning effect in the topical glucocorticoid clobetasone butyrate.

Abstract	Clobetasone butyrate ointment has been shown to be more effective in treating psoriasis and eczema than flurandrenolone ointment yet to cause less epidermal thinning in a human experimental model. This is an indication that the clinical activity of topical glucocorticoids may not necessarily be inseparable from their propensity to cause atrophy of the skin.
Authors	D V Stevanovic, L Wilson, C G Sparkes
Journal	The British journal of dermatology (Br J Dermatol) Vol. 96 Issue 1 Pg. 67-70 (Jan 1977) ISSN: 0007-0963 [Print] England
PMID	320995 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References	Flurandrenolone clobetasone butyrate Betamethasone Clobetasol
Topics	Betamethasone (analogs & derivatives, pharmacology, therapeutic use) Cell Count Clinical Trials as Topic Clobetasol (analogs & derivatives) Eczema (drug therapy) Flurandrenolone (pharmacology, therapeutic use) Humans Psoriasis (drug therapy) Skin (cytology, drug effects)

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