Neutrophils in the Tumor Microenvironment.

Abstract

Neutrophils are the first responders to inflammation, infection, and injury. As one of the most abundant leukocytes in the immune system, neutrophils play an essential role in cancer progression, through multiple mechanisms, including promoting angiogenesis, immunosuppression, and cancer metastasis. Recent studies demonstrating elevated neutrophil to lymphocyte ratios suggest neutrophil as a potential therapeutic target and biomarker for disease status in cancer. This chapter will discuss the phenotypic and functional changes in the neutrophil in the tumor microenvironment, the underlying mechanism(s) of neutrophil facilitated cancer metastasis, and clinical potential of neutrophils as a prognostic/diagnostic marker and therapeutic target.

• Authors: Lingyun Wu, Sugandha Saxena, Rakesh K Singh
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 1224 Pg. 1-20 ( 2020) ISSN: 0065-2598 [Print] United States
• PMID: 32036601 (Publication Type: Journal Article, Review)

Topics

• Humans
• Neoplasms (pathology)
• Neovascularization, Pathologic
• Neutrophils (pathology)
• Tumor Microenvironment