[Role of UHRF1 in methylation regulation and angiogenesis].

Abstract

Many recent studies have proved that ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an important nuclear protein associated with tumorigenesis, which plays a significant role in epigenetic regulation, especially in DNA methylation and histone methylation. For its particular domains, UHRF1 plays a critical role in biological behaviors including cell proliferation, cell cycle, and apoptosis. Overexpression of UHRF1 in various tumors is closely associated with the angiogenesis in tumors. This paper will provide a review of the regulation of UHRF1 in DNA methylation and histone methylation, and discuss the potential epigenetic role of UHRF1 in angiogenesis.

• Authors: Zi Guo, Zhaohui Mo
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 37 Issue 2 Pg. 200-204 (Feb 10 2020) ISSN: 1003-9406 [Print] China
• PMID: 32034755 (Publication Type: Journal Article, Review)

Chemical References

• CCAAT-Enhancer-Binding Proteins
• UHRF1 protein, human
• Ubiquitin-Protein Ligases

Topics

• CCAAT-Enhancer-Binding Proteins (genetics)
• DNA Methylation
• Epigenesis, Genetic
• Humans
• Neoplasms (genetics, pathology)
• Neovascularization, Pathologic (genetics)
• Ubiquitin-Protein Ligases (genetics)