Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential.

Abstract

Adipose-derived stem cells (ASCs) can self-renew and differentiate along multiple cell lineages. ASCs are also potently anti-inflammatory due to their inherent ability to regulate the immune system by secreting anti-inflammatory cytokines and growth factors that play a crucial role in the pathology of many diseases, including multiple sclerosis, diabetes mellitus, Crohn's, SLE, and graft-versus-host disease. The immunomodulatory effects and mechanisms of action of ASCs on pathological conditions are reviewed here.

• Authors: Sara Al-Ghadban, Bruce A Bunnell
• Journal: Physiology (Bethesda, Md.) (Physiology (Bethesda)) Vol. 35 Issue 2 Pg. 125-133 (03 01 2020) ISSN: 1548-9221 [Electronic] United States
• PMID: 32027561 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Adipose Tissue (cytology, immunology, metabolism)
• Animals
• Cell Differentiation
• Humans
• Mesenchymal Stem Cell Transplantation
• Mesenchymal Stem Cells (cytology, immunology, metabolism)
• Stem Cells (immunology)