Protective effect of D-pinitol on the experimental spinal cord injury in rats.

Abstract

Spinal cord injury (SCI) is the major cause of the spinal damage affecting motor and sensory function. Thus, the present study was conducted to investigate the effect of D-pinitol (PN) on spinal cord injury in rats. The PN showed to recover motor function near to normal via modulating oxidative stress, inflammatory response and cellular apoptosis in SCI rats. PN also causes modulation of Bcl2 family proteins and reduces the level of NF-ĸB and LOX-1 in dose dependent manner. The PN causes reduction of NLRP3, TNF-α and iNOS, with increase in caspase-1 together with modulation of MAPK mediators. It has been suggested that, D-pinitol exert protective action against SCI via inhibition of apoptosis, inflammation and oxidative stress, via modulating Bcl-2 genes and MAPK pathway.

• Authors: Yan An, Jianing Li, Yajun Liu, Mingxing Fan, Wei Tian
• Journal: Metabolic brain disease (Metab Brain Dis) Vol. 35 Issue 3 Pg. 473-482 (03 2020) ISSN: 1573-7365 [Electronic] United States
• PMID: 31997266 (Publication Type: Journal Article)

Chemical References

• NF-kappa B
• Neuroprotective Agents
• Proto-Oncogene Proteins c-bcl-2
• pinitol
• Inositol

Topics

• Animals
• Apoptosis (drug effects)
• Inflammation (drug therapy, metabolism, physiopathology)
• Inositol (analogs & derivatives, pharmacology, therapeutic use)
• Male
• NF-kappa B (metabolism)
• Neuroprotective Agents (pharmacology, therapeutic use)
• Oxidative Stress (drug effects)
• Proto-Oncogene Proteins c-bcl-2 (metabolism)
• Rats
• Rats, Sprague-Dawley
• Recovery of Function (drug effects, physiology)
• Signal Transduction (drug effects)
• Spinal Cord (drug effects, metabolism, physiopathology)
• Spinal Cord Injuries (drug therapy, metabolism, physiopathology)