[Resistant and progressive cutaneous lupus erythematosus treated with belimumab: A retrospective monocentric study].

Abstract

BACKGROUND:

Belimumab is currently approved for the treatment of active systemic lupus erythematosus (SLE). The aim of our study was to evaluate the efficacy of belimumab in the treatment of cutaneous lupus erythematosus (CLE), resistant to conventional therapy.

PATIENTS AND METHODS:

Seven patients with resistant and progressive LEC and treated with belimumab were retrospectively analyzed. The efficacy and safety of belimumab were evaluated with the CLASI, RCLASI and DLQI scores, after 6 to 12 months of treatment.

RESULTS:

Eighty-three percent of patients demonstrated a significant clinical improvement based on the CLASI and RCLASI activity scores, including 1 complete and 4 partial responses, without worsening of CLASI and RCLASI damage scores. Eighty percent of patients also showed an improvement of their quality of life (DLQI). Oral corticosteroids were discontinued in all patients. Tolerance was acceptable with only one serious adverse event (bacteriema).

CONCLUSION:

Our study suggests the clinical efficiency of belimumab in a series of 7 patients presenting a resistant and progressive CLE.

• Authors: F Dresco, E Puzenat, M Delobeau, D Salard, T Lihoreau, F Pelletier, F Aubin
• Journal: La Revue de medecine interne (Rev Med Interne) Vol. 41 Issue 3 Pg. 152-159 (Mar 2020) ISSN: 1768-3122 [Electronic] France
• Vernacular Title: Lupus érythémateux cutanés réfractaires traités par bélimumab : étude descriptive monocentrique.
• PMID: 31980188 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

Chemical References

• Adrenal Cortex Hormones
• Antibodies, Monoclonal, Humanized
• Immunosuppressive Agents
• belimumab

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Aged
• Aged, 80 and over
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Cohort Studies
• Disease Progression
• Drug Resistance (drug effects)
• Female
• France
• Humans
• Immunosuppressive Agents (therapeutic use)
• Lupus Erythematosus, Cutaneous (drug therapy, pathology)
• Male
• Middle Aged
• Retrospective Studies
• Treatment Outcome