Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: The Swedish Obese Subjects study is a prospective matched study performed at 25 surgical departments and 480 primary health care centers. Participants aged 37-60 years with BMI ≥34 kg/m2 (men) or ≥38 kg/m2 (women) were recruited between 1987 and 2001; 2,007 participants received bariatric surgery and 2,040 usual care. Self-reported body weight at 20 years of age was used to stratify patients into subgroups with normal BMI (<25 kg/m2), overweight (BMI 25-29.9 kg/m2), or obesity (BMI ≥30 kg/m2). Body weight, energy intake, and type 2 diabetes status were examined over 10 years, and incidence of cardiovascular and microvascular disease was determined over up to 26 years using data from health registers. RESULTS: There were small but statistically significant differences in reduction of body weight among the subgroups after bariatric surgery (interaction P = 0.032), with the largest reductions among those with obesity aged 20 years. Bariatric surgery increased type 2 diabetes remission (odds ratios 4.51, 4.90, and 5.58 in subgroups with normal BMI, overweight, or obesity at 20 years of age, respectively; interaction P = 0.951), reduced type 2 diabetes incidence (odds ratios 0.15, 0.13, and 0.15, respectively; interaction P = 0.972), and reduced microvascular complications independent of obesity status at 20 years of age (interaction P = 0.650). The association between bariatric surgery and cardiovascular disease was similar in the subgroups (interaction P = 0.674). Surgical complications were similar in the subgroups. CONCLUSIONS:
|
Authors | Felipe M Kristensson, Johanna C Andersson-Assarsson, Per-Arne Svensson, Björn Carlsson, Markku Peltonen, Lena M S Carlsson |
Journal | Diabetes care
(Diabetes Care)
Vol. 43
Issue 4
Pg. 860-866
(04 2020)
ISSN: 1935-5548 [Electronic] United States |
PMID | 31974103
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Copyright | © 2020 by the American Diabetes Association. |
Topics |
- Adult
- Age of Onset
- Aged
- Bariatric Surgery
(statistics & numerical data)
- Case-Control Studies
- Diabetes Mellitus, Type 2
(complications, epidemiology, surgery)
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Obesity
(complications, epidemiology, surgery)
- Overweight
(complications, epidemiology, surgery)
- Prospective Studies
- Sweden
(epidemiology)
- Treatment Outcome
- Young Adult
|