Impact of Blood Transfusion on the Prevalence of HHpgV-1, HPgV-1, and B19V Among Iranian HCV-infected Patients With Hemophilia.

Abstract

OBJECTIVE:

Blood-derived products from patient with hemophilia treated by factor VIII concentrates are potential sources of transfusion-transmitted infections, including human immunodeficiency virus, hepatitis, human pegivirus-1 (HPgV-1), B19 virus, and also human hepegivirus-1 (HHpgV-1). In the current study, we investigated the impact of blood transfusion on the prevalence of HHpgV-1, HPgV-1, and B19 virus in plasma of Iranian patient with hemophilia after direct-acting antiviral treatment of hepatitis C virus (HCV) infections for the first time.

MATERIALS AND METHODS:

A total of 170 patients with hemophilia who received direct-acting antivirals were enrolled in this study. Among them, 92 patients had a history of blood transfusion. The presence of HHpgV-1, HPgV-1, and B19 virus was detected by nested polymerase chain reaction analysis using the conserved primers. The plasmids harboring 5'-UTR and NS3 were used as positive controls for HPgV-1 and HHpgV-1, respectively.

RESULTS:

Our data identified 3 individuals with HHpgV-1 viremia (1.76%), 11 individuals with HPgV-1 viremia (6.47%), and 33 individuals with B19 viremia (19.4%). All patients were negative for hepatitis B virus, human immunodeficiency virus, and HCV infections. These findings indicated lower transmissibility or higher rates of virus clearance for HHpgV-1, HPgV-1, and B19 virus as compared with other bloodborne human flaviviruses such as HCV. However, the prevalence of B19 virus was significantly higher than the other 2 viruses.

CONCLUSION:

In general, these findings showed that the history of blood transfusion could increase the risk of viral transmission of bloodborne viruses among patient with hemophilia.

• Authors: Elnaz Agi, Samira Hojjatipour, Ali Namvar, Azam Bolhassani
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 42 Issue 4 Pg. e213-e218 (05 2020) ISSN: 1536-3678 [Electronic] United States
• PMID: 31972722 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• DNA, Viral

Topics

• Adolescent
• Adult
• Blood Transfusion
• Child
• Child, Preschool
• Cross-Sectional Studies
• DNA, Viral (blood)
• Erythema Infectiosum (blood, epidemiology, etiology)
• Female
• Hemophilia A (blood, epidemiology, therapy, virology)
• Hepacivirus (metabolism)
• Hepatitis C (blood, epidemiology, therapy, virology)
• Humans
• Iran (epidemiology)
• Male
• Middle Aged
• Parvovirus B19, Human (metabolism)
• Prevalence