Chemokine (C-C motif)
ligand 4 (CCL4) and
vascular endothelial growth factor-A (
VEGF-A) are involved in the progression and
metastasis of some
tumors, including
ovarian cancer,
colon cancer and
prostate cancer. However, the roles of CCL4 and
VEGF-A in human
endometrial cancer (EC) are still unclear. Here, we demonstrated that the production of CCL4 and
VEGF-A was significantly higher in EC tissues than in normal tissues, and their expression profiles were associated with the clinical stage of EC. In addition, we found that CCL4 promoted the angiogenesis and invasive ability of EC
tumors by increasing the production of
VEGF-A. We further confirmed the effect of CCL4 in the growth of EC
tumors by silencing the expression of CCL4 in EC cell lines. Finally, we found that CCL4 upregulated
VEGF-A expression by activating STAT3, and it enhanced the progression and
metastasis of EC. Our study showed that CCL4 promoted
tumor growth by upregulating
VEGF-A expression, which affected the STAT3 signal pathway in the EC cells.