A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema.

Abstract

We experienced a rare case of drug-induced hypersensitivity syndrome (DIHS) in which salazosulfapyridine (SASP) reactivated human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV), which resulted in a relapse of skin symptoms after changing to mizoribine. At the time of recurrence of skin erythema after the initiation of mizoribine, the serum DNA titers of not HHV-6 but CMV were elevated. A drug-induced lymphocyte stimulation test was negative for mizoribine but positive for SASP. In this case, DIHS developed with SASP in association with HHV-6 and CMV reactivation. The immunocompromised state induced by herpes virus reactivation and mizoribine might have caused the relapse of skin erythema.

• Authors: Saori Itoi-Ochi, Yukinobu Nakagawa, Atsushi Tanemura, Makoto Hirao, Manabu Fujimoto
• Journal: Case reports in dermatology (Case Rep Dermatol) 2019 Sep-Dec Vol. 11 Issue 3 Pg. 334-337 ISSN: 1662-6567 [Print] Switzerland
• PMID: 31966030 (Publication Type: Case Reports)
• Copyright: Copyright © 2019 by S. Karger AG, Basel.