[Pharmacological study of the anti-inflammatory agent glyderinine].

Abstract

In experiments on various animals glyderinine, a derivative of glycyrrhizic acid isolated from Glycyrrhiza glabra, was found to exert a pronounced anti-inflammatory effect exceeding that of hydrocortisone and amidopyrine. The mechanism of the anti-inflammatory effect was to a certain degree related to the adrenal cortex, suppression of vascular permeability and antagonism to inflammation as well. Similarly to other anti-inflammatory agents, glyderinine possesses analgesic and antipyretic properties, but unlike them it fails to suppress hemopoiesis and to cause ulceration of the gastrointestinal mucosa. The drug is of low toxicity and exerts the antiallergic effect. Glyderinine was successfully tried and recommended for a wide use as an ointment for treating skin diseases.

• Authors: M M Azimov, U B Zakirov, Sh D Radzhapova
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1988 Jul-Aug Vol. 51 Issue 4 Pg. 90-3 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Farmakologicheskoe izuchenie protivovospalitel'nogo sredstva gliderinina.
• PMID: 3191985 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Xanthenes
• Xanthones
• mangiferin
• glyderinine
• Glycyrrhetinic Acid

Topics

• Adrenal Glands (physiology)
• Adrenalectomy
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use, toxicity)
• Arthritis (chemically induced, drug therapy)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Glycyrrhetinic Acid (analogs & derivatives, therapeutic use, toxicity)
• Mice
• Peritonitis (chemically induced, drug therapy)
• Rats
• Time Factors
• Xanthenes (pharmacology, therapeutic use)
• Xanthones