Abstract | BACKGROUND: Clinicopathological studies have demonstrated that the neuropsychological profiles and outcomes are different between two dementia subtypes, namely Alzheimer's disease (AD) and Lewy bodies-related disease. OBJECTIVE: METHODS: We enrolled 216 ADCI patients, 183 LBCI patients, and 30 controls. Cortical thickness and diffusion tensor imaging analyses were performed to correlate gray matter and white matter (WM) abnormalities to cognitive composite scores for memory, visuospatial, and attention/executive domains in the ADCI spectrum ( ADCI patients and controls) and the LBCI spectrum (LBCI patients and controls) separately. RESULTS: Memory dysfunction correlated with cortical thinning and increased mean diffusivity in the AD-prone regions, particularly the medial temporal region, in ADCI. Meanwhile, it only correlated with increased mean diffusivity in the WM adjacent to the anteromedial temporal, insula, and basal frontal cortices in LBCI. Visuospatial dysfunction correlated with cortical thinning in posterior brain regions in ADCI, while it correlated with decreased fractional anisotropy in the corpus callosum and widespread WM regions in LBCI. Attention/executive dysfunction correlated with cortical thinning and WM abnormalities in widespread brain regions in both disease spectra; however, ADCI had more prominent correlation with cortical thickness and LBCI did with fractional anisotropy values. CONCLUSIONS:
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Authors | Seok Jong Chung, Seun Jeon, Han Soo Yoo, Yang Hyun Lee, Mijin Yun, Seung-Koo Lee, Phil Hyu Lee, Young Ho Sohn, Alan C Evans, Byoung Seok Ye |
Journal | Journal of Alzheimer's disease : JAD
(J Alzheimers Dis)
Vol. 73
Issue 3
Pg. 873-885
( 2020)
ISSN: 1875-8908 [Electronic] Netherlands |
PMID | 31868668
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Alzheimer Disease
(diagnostic imaging, physiopathology, psychology)
- Attention
(physiology)
- Brain
(diagnostic imaging, physiopathology)
- Cognition
(physiology)
- Cognitive Dysfunction
(diagnostic imaging, physiopathology, psychology)
- Diffusion Tensor Imaging
- Executive Function
(physiology)
- Female
- Gray Matter
(diagnostic imaging, physiopathology)
- Humans
- Lewy Bodies
- Lewy Body Disease
(diagnostic imaging, physiopathology, psychology)
- Male
- Memory
(physiology)
- Middle Aged
- Neuropsychological Tests
- White Matter
(diagnostic imaging, physiopathology)
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