5- aminocarbonyl- 10,11- dihydro- 5H- dibenzo(a,d)cyclohepten- 5,10- imine (ADCI)

01/01/1999 - "The present study has resulted in the development of simple, reproducible flow cytometry-based GIA and ADCI assays, and also provides baseline information for further investigation of the role of ADCI activity in naturally acquired immune protection against malaria."
04/01/2015 - "High ADCI activity was significantly associated with reduced risk against malaria. "
01/01/2013 - "Protective immunity against malaria requires the induction of humoral, antibody-dependent cellular inhibition (ADCI) and effector and memory cell responses. "
10/01/2009 - "Data showed that, during a malaria attack, some patients' MO can exert a strong ADCI activity. "
09/01/1994 - "Accordingly, an assay of antibody-dependent cellular inhibition (ADCI) of parasite growth was used as a means of selecting for molecules capable of inducing protective immunity to malaria. "

10/01/1991 - "In common with other NMDA antagonists, ADCI retarded the development of amygdaloid kindled seizures in rats, but failed to attenuate the afterdischarge duration in fully kindled animals. "
10/01/1991 - "ADCI was also protective against chemically induced seizures in mice, including those produced by 4-aminopyridine (ED50, 7.1 mg/kg s.c.) and pentylenetetrazol (ED50, 37.4 mg/kg s.c.). "
07/01/1998 - "ADCI is a mild NMDA antagonist and a use-dependent blocker of voltage-gated sodium channels, the combined effect of which, in preclinical studies, has been improved efficacy in the treatment of epileptic seizures. "
03/01/1992 - "ADCI and dizocilpine suppressed the severity and occurrence of the withdrawal seizures in a dose-dependent fashion, whereas carbamazepine was ineffective in blocking the withdrawal seizures. "
03/13/1992 - "In contrast to the lack of activity of other NMDA antagonists, phencyclidine and ADCI [(+/-)-aminocarbonyl-10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5,10-imine] were potent antagonists of DTX-induced seizures."

10/01/2009 - "In the group of patients with the highest percentages and absolute numbers of CD14(hi)CCR2+CX3CR1+ MO and the highest mean levels of ADCI activity, blood parasitemias were lower (0.14+/-0.34%) than in the second group (1.30+/-3.34%; p = 0.0053). "
08/01/2011 - "Interestingly, in the ADCI test, higher levels of tumour necrosis factor alpha (TNF-α) were observed in the supernatant from cultures with higher parasitemias. "
05/01/2001 - "The results suggest that, among the different isotypes present in the serum of semi-immune individuals, parasite antigen-specific IgG3 in particular may play an important role in controlling parasitemia via an ADCI mechanism involving monocyte- derived mediators."
08/01/1995 - "Results obtained so far suggest that (a) merozoite uptake by monocytes (MN) as well as by polymorphonuclear cells has little influence on the course of parasitemia; (b) the ADCI effect is mediated by a soluble factor released by MN; (c) this or these factors are able to block the division of surrounding intraerythrocytic parasites at the one nucleus stage; (d) the critical triggering antigen(s) targeted by effective Abs would appear to be associated with the surface of merozoites, as opposed to that of infected red blood cells; (e) the MN receptor for Abs effective in ADCI is apparently Fc gamma RII, and not RI; (f) MN function is up- and down-regulated by interferon-gamma and interleukin 4, respectively; and (g) of several potential mediators released by MN, only tumor necrosis factor (TNF) proved of relevance. "

03/01/2000 - "The combination of these two mechanisms of action makes SGB-017 an effective AED in several different animal models of epilepsy."
03/01/2000 - "However, SGB-017 is effective in several animal models of epilepsy that are unresponsive to NMDA antagonists. "
07/01/1998 - "ADCI is an NMDA antagonist and a sodium channel antagonist which is under development by Neurogen and Wyeth-Ayerst as a potential treatment for epilepsy, seizures and stroke. "

01/01/2020 - "Our study demonstrated that ADCI and LBCI have different neural correlates with respect to cognitive dysfunction. "
01/01/2021 - "We consecutively recruited 57 patients with pure AD-related cognitive impairment (ADCI), 49 with pure LBD-related cognitive impairment (LBCI), 45 with mixed ADCI/LBCI, and 34 controls. "
01/01/2021 - "We investigated the relationship between ADCI, LBCI, graph theory-based network measures on diffusion tensor images, and cognitive dysfunction using general linear models after controlling for age, sex, education, deep WM hyperintensities (WMH), periventricular WMH, and intracranial volume. "
01/01/2021 - "We consecutively recruited 37 controls and 77 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI). "
01/01/2020 - "The association between Aβ/tau and cognitive decline is stronger in SVCI than in ADCI. "