Antipsychotic-like profile of CIQ isomers in animal models of schizophrenia.

Abstract

Earlier, we have shown the efficacy of racemic (±) CIQ, a positive allosteric modulator of GluN2C/2D receptor against MK-801 induced impairment of prepulse inhibition as well as working memory. The present study investigated the antipsychotic-like profile of different CIQ (±, +, -) isomers against schizophrenia-like symptoms in series of behavioural animal models like apomorphine climbing, social isolation behaviour and NMDA receptor antagonist MK-801 induced cognitive deficits. Further, we also tested CIQ (±, +, -) isomers in neurodevelopmental model against MK-801induced deficits using open field test, Y-maze test and novel object recognition test. CIQ (±, +, -) isomers decreased climbing behaviour, increased social interaction and improved the MK-801 induced deficits in working memory in Y-maze. Further, CIQ (±, +) but not CIQ (-) improved the recognition memory in novel object recognition test as well as reduced hyperlocomotion and stereotyped behaviour. We conclude that CIQ (±, +) but not CIQ (-) exhibit the significant antipsychotic-like profile.

• Authors: Pushparaj Gawai, Rohit Upadhyay, Sukanya G Gakare, Lopmudra Sarode, Shashank M Dravid, Rajesh R Ugale
• Journal: Behavioural pharmacology (Behav Pharmacol) Vol. 31 Issue 6 Pg. 524-534 (09 2020) ISSN: 1473-5849 [Electronic] England
• PMID: 31860561 (Publication Type: Journal Article)

Chemical References

• Antipsychotic Agents
• NR2C NMDA receptor
• NR2D NMDA receptor
• Receptors, N-Methyl-D-Aspartate
• Dizocilpine Maleate
• Apomorphine

Topics

• Animals
• Antipsychotic Agents (pharmacology)
• Apomorphine (pharmacology)
• Disease Models, Animal
• Dizocilpine Maleate (pharmacology)
• Male
• Maze Learning
• Mice
• Receptors, N-Methyl-D-Aspartate (drug effects)
• Schizophrenia (drug therapy)
• Social Interaction (drug effects)
• Stereoisomerism
• Stereotyped Behavior (drug effects)