Abstract | OBJECTIVE: METHODS: One hundred and twenty four patients who had muscle cramps three or more times weekly were included. They were divided into two arms: 62 patients administrated orphenadrine and 62 administrated placebo. They were followed up till 2 weeks after the end of therapy. Muscle cramps were evaluated using questionnaire as regards severity, duration, and frequency. Also, side effects of orphenadrine were recorded. RESULTS: Frequency, duration of muscle cramps, and pain score improved significantly after 1 month of orphenadrine therapy in comparison to placebo. Few side effects were recorded in the form of dry mouth, drowsiness, and nausea. CONCLUSION:
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Authors | Sherief Abd-Elsalam, Shaimaa Ebrahim, Shaimaa Soliman, Walaa Alkhalawany, Asem Elfert, Nehad Hawash, Mahmoud Elkadeem, Rehab Badawi |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 32
Issue 8
Pg. 1042-1045
(08 2020)
ISSN: 1473-5687 [Electronic] England |
PMID | 31834056
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Humans
- Liver Cirrhosis
(complications)
- Muscle Cramp
(drug therapy, etiology)
- Orphenadrine
- Pain
- Treatment Outcome
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