The role of 18F-FDG PET/CT-based quantitative metabolic parameters in patients with ovarian clear cell carcinoma.

Abstract

BACKGROUND:

Ovarian clear cell carcinoma (CCC) is enriched in genes associated with glucose metabolism.

OBJECTIVE:

To evaluate the 18F-FDG PET/CT-based metabolic variables and the correlations with clinicopathologic features in OCCC patients.

METHODS:

We measured quantitative parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG).

RESULTS:

A total of 22 patients were included. PET/CT-based metabolic parameters were calculated for 20 patients because two had low glucose-uptake tumor. The median SUVmax was 7.25 (range 2.50-14.80). Spearman's correlation test revealed that the level of pre-operative serum cancer antigen 125 (CA 125) correlated significantly with MTV (P= 0.020) and TLG (P= 0.023). Interestingly, platinum-sensitive patients tended to have higher MTV/TLG though significance not achieved. On univariate analysis, the following four variables (stage, residual disease, platinum sensitivity and MTV50) were significant for both progression-free survival and overall survival. Besides, four metabolic parameters (MTV40, TLG40, TLG50 and TLG60) were significantly associated with patients' overall survival. Out of expectation, ovarian CCC patients with higher level of MTV/TLG tended to have better survival.

CONCLUSIONS:

18F-FDG PET/CT-based metabolic volumetric parameters might be predicators for survival in ovarian CCC patients. Cautions should be taken when interpreting the results due to the small sample size.

• Authors: Shuang Ye, Shuai Liu, Shuling Zhou, Libing Xiang, Xiaohua Wu, Huijuan Yang
• Journal: Cancer biomarkers : section A of Disease markers (Cancer Biomark) Vol. 27 Issue 2 Pg. 189-194 ( 2020) ISSN: 1875-8592 [Electronic] Netherlands
• PMID: 31796665 (Publication Type: Journal Article)

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18
• Glucose

Topics

• Adenocarcinoma, Clear Cell (diagnostic imaging, drug therapy, metabolism, pathology)
• Adult
• Aged
• Aged, 80 and over
• Female
• Fluorodeoxyglucose F18
• Glucose (metabolism, pharmacokinetics)
• Glycolysis
• Humans
• Middle Aged
• Ovarian Neoplasms (diagnostic imaging, drug therapy, metabolism, pathology)
• Positron Emission Tomography Computed Tomography (methods)
• Prognosis
• Radiopharmaceuticals
• Retrospective Studies
• Survival Rate
• Tumor Burden