Antitumor activity of a new fluoropyrimidine derivative, 5'-deoxy-5-fluorouridine, against murine and human experimental tumors.

Abstract

5'-Deoxy-5-fluorouridine (5'-DFUR) was evaluated for antitumor activity against four murine tumors (L1210 leukemia, P388 leukemia, Lewis lung carcinoma, and B16 melanoma) and a human mammary carcinoma (MX-1) xenografted in athymic mice. Intraperitoneal administration of 5'-DFUR was ineffective against B16 melanoma implanted intraperitoneally and showed less marked antitumor activity against P388 and L1210 leukemias implanted intraperitoneally or intravenously as compared with that of 5-fluorouracil (5-FU) or 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207), while oral administration of 5'-DFUR showed a similar or superior antitumor activity to that of 5-FU or FT-207 against L1210 leukemia implanted subcutaneously. 5'-DFUR showed a marked antitumor activity against MX-1 implanted subcutaneously and also showed slight antitumor activity against Lewis lung carcinoma implanted subcutaneously, while 5-FU and FT-207 did not show any significant antitumor activity against these tumors. These results suggest that 5'-DFUR may be worthy of clinical trial against solid tumors, especially cancers of the breast.

• Authors: S Fujimoto, Y Wang, K Inoue, M Ogawa
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 76 Issue 7 Pg. 644-50 (Jul 1985) ISSN: 0910-5050 [Print] Japan
• PMID: 3161854 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Floxuridine
• doxifluridine

Topics

• Animals
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Breast Neoplasms (drug therapy)
• Female
• Floxuridine (administration & dosage, therapeutic use)
• Humans
• Leukemia L1210 (drug therapy)
• Leukemia P388 (drug therapy)
• Male
• Melanoma (drug therapy)
• Mice
• Mice, Nude
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)