[Thiamin and alcohol use disorder: A national survey of practice].

Abstract

OBJECTIVE:

The survey aimed to estimate, in the presence of alcohol use disorder, the frequency of systematic prescription of thiamine, the factors associated with it, and those related to the administration (oral, intravenous, intramuscular) when Wernicke's encephalopathy is suspected.

METHODS:

A self-questionnaire available on Internet was sent by e-mail to doctors and nurses taking care patients with alcohol use disorder.

RESULTS:

In all, 565 professionals responded. The systematic prescription frequency of thiamine was 84.8 %, addiction care centers and medical-psychological centers prescribed it 5 times less than in psychiatric hospitals (OR=0.2 IC [0.1-0.5] P<0.0001), and medicine/surgery/obstetrics (MSO) services 10 times more than psychiatric hospitals (OR=10.7 IC [2.5-45.3] P<0.0001). The prescription decreased with the exercise period, the interns prescribing it 10 times more systematically (OR=10.9 IC [3.6-32.9] P<0.0001). In the presence of symptoms related to Wernicke's encephalopathy, thiamine administration was mainly oral (67.1 %). Intravenous administration was used more by the MSO services (OR=18.3 IC [10.2-32.7] P<0.0001), while the intramuscular injection was used more in psychiatric hospitals (OR=4.6 IC [1.7-11.9] P=0.0353).

CONCLUSION:

The prescription of thiamine is rather systematic. In contrast, intravenous administration is underused, in the presence of symptoms related to Wernicke's encephalopathy, in favor of oral administration, and the more specific use of the intramuscular injection in psychiatry.

• Authors: Laura Collet, Michaël Bisch, Sarah Viennet, Raymund Schwan, François Paille
• Journal: Therapie (Therapie) 2020 May - Jun Vol. 75 Issue 3 Pg. 281-294 ISSN: 1958-5578 [Electronic] France
• Vernacular Title: Thiamine et trouble de l’usage d’alcool : une enquête de pratique nationale.
• PMID: 31587815 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2019 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.

Chemical References

• Thiamine

Topics

• Adult
• Alcoholism (complications, drug therapy, epidemiology)
• Clinical Competence (statistics & numerical data)
• Cross-Sectional Studies
• Drug Administration Routes
• Female
• France (epidemiology)
• Geography
• Humans
• Male
• Middle Aged
• Practice Patterns, Physicians' (statistics & numerical data)
• Risk Factors
• Substance Withdrawal Syndrome (drug therapy, epidemiology)
• Surveys and Questionnaires
• Thiamine (administration & dosage, therapeutic use)
• Wernicke Encephalopathy (drug therapy, epidemiology, etiology)