Abstract |
The clinical implications of airflow limitation severity and blood eosinophil level in patients with chronic obstructive pulmonary disease ( COPD) and prolonged mechanical ventilation (PMV) are unknown. Thus, this study aimed to identify whether or not these two indicators were significantly associated with short-term in-respiratory care center (RCC) treatment outcomes in this population. Of all participants (n = 181) in this retrospective cross-sectional study, 41.4%, 40.9%, 8.3%, and 52.5% had prolonged RCC admission (RCC length of stay >21 days), failed weaning, death, and any adverse outcomes of interest, respectively. Compared to participants without any adverse outcomes of interest, moderate (the Global Initiative for Chronic Obstructive Lung Disease ( GOLD) II) and/or severe ( GOLD III) airflow limitation were significantly associated with short-term in-RCC adverse outcomes in terms of failed weaning (for III versus I, OR = 15.06, p = 0.003) and having any adverse outcomes of interest (for II versus I, OR = 17.66, p = 0.002; for III versus I, OR = 37.07, p = 0.000) though the severity of airflow limitation did not have associations with prolonged RCC admission and death after adjustment. Meanwhile, blood eosinophilia defined by various cut-off values was not associated with any adverse outcomes. The findings have significant clinical implications and are useful in the management of patients with COPD and PMV.
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Authors | Wei-Chang Huang, Chen-Cheng Huang, Pi-Chu Wu, Chao-Jung Chen, Ya-Hua Cheng, Hui-Chen Chen, Ching-Hsiao Lee, Ming-Feng Wu, Jeng-Yuan Hsu |
Journal | Scientific reports
(Sci Rep)
Vol. 9
Issue 1
Pg. 13420
(09 17 2019)
ISSN: 2045-2322 [Electronic] England |
PMID | 31530874
(Publication Type: Journal Article)
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Topics |
- Aged
- Aged, 80 and over
- Cross-Sectional Studies
- Eosinophils
- Female
- Forced Expiratory Volume
- Humans
- Leukocyte Count
- Male
- Pulmonary Disease, Chronic Obstructive
(blood, physiopathology, therapy)
- Respiration, Artificial
- Respiratory Center
- Retrospective Studies
- Risk Factors
- Treatment Outcome
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