Combination therapy with salicylic acid chemical peels, glycyrrhizin compound, and vitamin C for Riehl's melanosis.

Abstract

BACKGROUND:

Riehl's melanosis is a chronic, refractory disorder, which can adversely affect patient's quality of life. Intense pulse light, neodymium-doped yttrium aluminum garnet laser, hydroquinone, tranexamic acid have been reported to treat this disease, but there have been few reports on the effectiveness of other treatments.

AIM:

To assess the efficacy and safety of triple combination therapy with salicylic acid chemical peels, oral glycyrrhizin compound, and vitamin C for Riehl's melanosis.

PATIENTS/METHODS:

Three patients diagnosed with Riehl's melanosis were enrolled. All patients were treated with glycyrrhizin compound (150 mg/d), vitamin C (100 mg/d), and salicylic acid 30% peels once every 2 weeks. Clinical photographs and VISIA were used to assess the efficacy.

RESULTS:

All patients received obvious improvement and reported no obvious side effects.

CONCLUSION:

Triple combination therapy with salicylic acid peels, oral glycyrrhizin compound, and vitamin C is a safe and effective modality for Riehl's melanosis.

• Authors: Lian Wang, Xiang Wen, Dan Hao, Yong Li, Dan Du, Xian Jiang
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 19 Issue 6 Pg. 1377-1380 (Jun 2020) ISSN: 1473-2165 [Electronic] England
• PMID: 31524950 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• Glycyrrhizic Acid
• Salicylic Acid
• Ascorbic Acid

Topics

• Administration, Cutaneous
• Administration, Oral
• Adult
• Ascorbic Acid (administration & dosage)
• Chemexfoliation (adverse effects, methods)
• Combined Modality Therapy (adverse effects, methods)
• Drug Therapy, Combination (adverse effects, methods)
• Female
• Glycyrrhizic Acid (administration & dosage, adverse effects)
• Humans
• Male
• Melanosis (therapy)
• Middle Aged
• Salicylic Acid (administration & dosage, adverse effects)
• Treatment Outcome