[Ceftriaxone-resistant Streptococcus pneumoniae meningitis: case report].

Abstract

Infectious meningitis is a medical emergency. Within the spectrum of infectious agents, the most important is Streptococcus pneumoniae, the most frequent etiological agent of bacterial meningitis. The initiation of empirical antimicrobial treatment bears great importance and considers third-generation cephalosporins as the first alternative. However, cases of ceftriaxone resistance have been reported in several regions of the world. This has become an emerging problem in need of reconsideration of the current empirical antibiotic treatment schemes. We present the case of a 56-year old man with acute infectious meningitis caused by ceftriaxone-resistant Streptococcus pneumoniae, who responded favorably to combined empirical treatment with ceftriaxone and vancomycin and to whom, during his hospital stay, the presence of hypothyroidism and mega cisterna magna was diagnosed.

• Authors: Marcos Saavedra-Velasco, Mariel Tapia-Cruz, J Antonio Grandez-Urbina, Saarah Zegarra Del Rosario-Alvarado, Fernando Mendo-Urbina, Rafael Pichardo-Rodriguez
• Journal: Revista peruana de medicina experimental y salud publica (Rev Peru Med Exp Salud Publica) 2019 Apr-Jun Vol. 36 Issue 2 Pg. 349-352 ISSN: 1726-4642 [Electronic] Peru
• Vernacular Title: Meningitis por Streptococcus pneumoniae resistente a ceftriaxona: reporte de un caso.
• PMID: 31460651 (Publication Type: Case Reports)

Chemical References

• Anti-Bacterial Agents
• Vancomycin
• Ceftriaxone

Topics

• Anti-Bacterial Agents (administration & dosage)
• Ceftriaxone (administration & dosage)
• Drug Resistance, Bacterial
• Drug Therapy, Combination
• Humans
• Male
• Meningitis, Pneumococcal (drug therapy, microbiology)
• Microbial Sensitivity Tests
• Middle Aged
• Streptococcus pneumoniae (isolation & purification)
• Treatment Outcome
• Vancomycin (administration & dosage)