Abstract | BACKGROUND: METHODS: RESULTS: GPR64 levels were remarkably lower in 10 of 21 (47.62%) of endometrial carcinoma samples compared to control. Depletion of GPR64 by siRNA transfection revealed an increase of colony formation ability, cell proliferation, cell migration, and invasion activity in Ishikawa and HEC1A cells. The expression of Connexin 43 ( Cx43), a member of the large family of gap junction proteins, was reduced through activation of AMP-activated protein kinase (AMPK) in Ishikawa cells with GPR64-deficicy. CONCLUSIONS:
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Authors | Jong Il Ahn, Jung-Yoon Yoo, Tae Hoon Kim, Young Im Kim, Russell R Broaddus, Ji Yeon Ahn, Jeong Mook Lim, Jae-Wook Jeong |
Journal | BMC cancer
(BMC Cancer)
Vol. 19
Issue 1
Pg. 810
(Aug 14 2019)
ISSN: 1471-2407 [Electronic] England |
PMID | 31412816
(Publication Type: Journal Article)
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Chemical References |
- ADGRG2 protein, human
- Connexin 43
- GJA1 protein, human
- RNA, Small Interfering
- Receptors, G-Protein-Coupled
- AMP-Activated Protein Kinases
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Topics |
- AMP-Activated Protein Kinases
(metabolism)
- Carcinoma, Endometrioid
(genetics, metabolism, pathology)
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Connexin 43
(metabolism)
- Endometrial Neoplasms
(genetics, metabolism, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Neoplasm Invasiveness
- Phosphorylation
- RNA, Small Interfering
- Receptors, G-Protein-Coupled
(antagonists & inhibitors, genetics, metabolism)
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