Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota.

Abstract

This study evaluated the effects of long-chain bases from sea cucumber (SC-LCBs) on modulation of the gut microbiota and inhibition of obesity in high fat diet-fed mice. Results showed that SC-LCBs exerted significant antiobese effects, which were associated with the inhibition of hyperglycemia and lipid accumulation. SC-LCBs also regulated serum adipocytokines toward to normal levels. SC-LCBs caused significant decreases in Firmicutes, Actinobacteria phylum, and obesity-related bacteria (Desulfovibro, Bifidobacterium, Romboutsia etc. genus). SC-LCBs also elevated Bacteroidetes, Proteobacteria, Verrucomicrobia phylum, and short chain fatty acids (SCFAs)-producing bacteria (Bacteroides, Lactobacillus, Lachnospiraceae_NK4A136_group etc. genus). Moreover, serum and fecal lipoplysaccharide (LPS) concentrations and its dependent toll-line receptor 4 pathway were inhibited by SC-LCBs treatment. SC-LCBs caused increases in fecal SCFAs and their mediated G-protein-coupled receptors proteins. These suggest that SC-LCBs alleviate obesity by altering gut microbiota. Thus, it sought to indicate that SC-LCBs can be developed as food supplement for the obesity control and the human gut health.

• Authors: Shiwei Hu, Yangli Xu, Xiang Gao, Shijie Li, Wei Jiang, Yu Liu, Laijin Su, Huicheng Yang
• Journal: Marine drugs (Mar Drugs) Vol. 17 Issue 8 (Aug 01 2019) ISSN: 1660-3397 [Electronic] Switzerland
• PMID: 31374958 (Publication Type: Journal Article)

Chemical References

• Glycosphingolipids

Topics

• Animals
• Bacteria (drug effects, isolation & purification, metabolism)
• Diet, High-Fat (adverse effects)
• Dietary Supplements
• Disease Models, Animal
• Feces (microbiology)
• Gastrointestinal Microbiome (drug effects)
• Glycosphingolipids (administration & dosage, isolation & purification)
• Humans
• Intestinal Mucosa (microbiology)
• Male
• Mice
• Obesity (diet therapy, etiology, microbiology)
• Sea Cucumbers (chemistry)