Chronic inflammatory demyelinating
polyneuropathy (
CIDP) is a chronically progressive or relapsing sensorimotor disorder presumably due to antibody-mediated reactions. It is a rare condition in children, with estimated prevalence as 0.48 per 100,000 among patients younger than 20 years of age. Recommended treatments include immune modulators,
intravenous immunoglobulins (IVIgs),
steroids, and
plasmapheresis. Management of pediatric
CIDP is challenging because of the lack of evidence-based efficacy of the current
therapies in children. Because of the rarity of this condition, there are no double-blind randomized studies to support the therapeutic choice as well as to identify the optimal first-line therapeutic regimen. IVIgs are widely used but the
intravenous administration is usually uncomfortable, especially for children. Subcutaneous
immunoglobulins (SCIgs) have proven to be effective in adults with
CIDP and in children affected by antibody deficiencies and other different immune and inflammatory disorders. Herein, we described the case of a 7-year-old boy, affected by
CIDP who clinically responded to
IVIg but was dependent on this
therapy. In order to improve his quality of life, we switched to SCIg with excellent result.