Insulin Resistance and Cardiovascular Risks in Different Groups of Hemodialysis Patients: A Multicenter Study.

Abstract

BACKGROUND:

To investigate the association between insulin resistance (IR) and cardiovascular disease (CVD) risks among hemodialysis patients.

METHODS:

We conducted a cross-sectional study between 2013 and 2017, on 384 hemodialysis patients from seven hospital-based-dialysis centers. HOMA-IR is classified according to median value. The CVD risks were defined by the K/DOQI Guidelines. Logistic regression analysis was used.

RESULTS:

Patients' age was 60.9 ± 11.8, 58.1% men, and 40.3% overweight/obese. The median of HOMA-IR was 5.4, 82.8% high systolic blood pressure, and 85.7% hyperhomocysteinemia. In multivariate analysis, IR was significantly associated with higher odds of low high-density lipoprotein cholesterol, high triglyceride, and impaired fasting glucose in groups of normal weight, overweight/obese, nondiabetes, diabetes, and overall sample. IR linked with elevated high-sensitive C-reactive protein in normal weight patients (odd ratio, OR=2.21, 95% confidence interval, 1.16-4.22, p < .05), with hypoalbuminemia in normal weight patients (OR=8.31, 95% CI, 2.35-29.37, p < .01), in nondiabetes patients (OR=6.59, 95% CI, 1.81-23.95, p < .01), and overall sample (OR=3.07, 1.51-6.23, p < .01).

CONCLUSIONS:

The level of IR and prevalence of CVD risks were high in hemodialysis patients. IR was independently associated with CVD risks.

• Authors: Tuyen Van Duong, Chun-Kuang Shih, Te-Chih Wong, Hsi-Hsien Chen, Tso-Hsiao Chen, Yung-Ho Hsu, Sheng-Jeng Peng, Ko-Lin Kuo, Hsiang-Chung Liu, En-Tzu Lin, Chien-Tien Su, Shwu-Huey Yang
• Journal: BioMed research international (Biomed Res Int) Vol. 2019 Pg. 1541593 ( 2019) ISSN: 2314-6141 [Electronic] United States
• PMID: 31309101 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Insulin
• Triglycerides

Topics

• Blood Pressure (physiology)
• Body Mass Index
• Cardiovascular Diseases (blood, etiology)
• Cross-Sectional Studies
• Female
• Humans
• Insulin (blood)
• Insulin Resistance (physiology)
• Male
• Metabolic Diseases (blood, etiology)
• Middle Aged
• Obesity (blood, complications)
• Overweight (blood, complications)
• Renal Dialysis (methods)
• Risk Factors
• Triglycerides (blood)