Macrophage activation syndrome in neonates born to mothers with adult-onset Still's disease: Perinatal effect of maternal IL-18.

Abstract

Overproduction of interleukin (IL)-18 is closely related to the pathogenesis of adult-onset Still's disease (AOSD) and the development of macrophage activation syndrome (MAS), a life-threating complication of AOSD. We reported three cases of MAS occurring in infants born to mothers with AOSD. The infants developed MAS at age 13 and 8 days and at birth. Serum IL-18 levels were extremely elevated in all infants (147,000 pg/mL; 378,000 pg/mL; 95,000 pg/mL) as well as in their mothers (58,500 pg/mL; 367,000 pg/mL; 84,000 pg/mL). Physicians should be aware that infants born to mothers with AOSD are at a risk of developing MAS. Serum IL-18 levels in mothers with AOSD and their infants should be monitored.

• Authors: Masaki Shimizu, Toshitaka Kizawa, Ryota Kato, Takayuki Suzuki, Akihiro Yachie
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 207 Pg. 36-39 (10 2019) ISSN: 1521-7035 [Electronic] United States
• PMID: 31299380 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Glucocorticoids
• Interleukin-18
• Dexamethasone
• Ferritins
• Prednisolone

Topics

• Adult
• Blood Transfusion
• Dexamethasone (therapeutic use)
• Female
• Ferritins (blood)
• Glucocorticoids (therapeutic use)
• Humans
• Infant, Newborn
• Interleukin-18 (blood)
• Macrophage Activation Syndrome (etiology)
• Male
• Prednisolone (therapeutic use)
• Still's Disease, Adult-Onset (complications)